Reaction Details Report a problem with these data
Target
Somatostatin receptor type 2
Ligand
BDBM50077288
Substrate
n/a
Meas. Tech.
ChEMBL_200687 (CHEMBL807098)
Ki
19±n/a nM
Citation
 Hocart, SJ; Jain, R; Murphy, WA; Taylor, JE; Coy, DH Highly potent cyclic disulfide antagonists of somatostatin. J Med Chem 42:1863-71 (1999) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50077288
Synonyms:
CHEMBL2372956 | H-Cpa-cyclo[DCys-Pal-DTrp-Lys-Tle-Cys]-Cpa-NH2
Type:
Small organic molecule
Emp. Form.:
C58H72Cl2N12O8S3
Mol. Mass.:
1232.369
SMILES:
C[C@@H](C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccnc2)NC(=O)[C@@H](CSSC[C@H](NC1=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(N)=O)NC(=O)[C@H](N)Cc1ccc(Cl)cc1)C1CCCS1
Structure:
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