Reaction Details Report a problem with these data
Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM50077979
Substrate
n/a
Meas. Tech.
ChEMBL_163344 (CHEMBL765226)
IC50
110±n/a nM
Citation
 Liverton, NJ; Butcher, JW; Claiborne, CF; Claremon, DA; Libby, BE; Nguyen, KT; Pitzenberger, SM; Selnick, HG; Smith, GR; Tebben, A; Vacca, JP; Varga, SL; Agarwal, L; Dancheck, K; Forsyth, AJ; Fletcher, DS; Frantz, B; Hanlon, WA; Harper, CF; Hofsess, SJ; Kostura, M; Lin, J; Luell, S; O'Neill, EA; O'Keefe, SJ Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase. J Med Chem 42:2180-90 (1999) [PubMed]  Article 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM50077979
Synonyms:
4-[5-(4-Fluoro-phenyl)-2-piperidin-3-yl-3H-imidazol-4-yl]-pyridine | CHEMBL67874
Type:
Small organic molecule
Emp. Form.:
C19H19FN4
Mol. Mass.:
322.3794
SMILES:
Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)C1CCCNC1
Structure:
Search PDB for entries with ligand similarity: