Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50017975
Substrate
n/a
Meas. Tech.
ChEMBL_1888981 (CHEMBL4390735)
Ki
1148±n/a nM
Citation
 Al-Ghanim, L; Zhu, XY; Asong, G; Ablordeppey, SY SYA 013 analogs as moderately selective sigma-2 (? Bioorg Med Chem 27:2421-2426 (2019) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50017975
Synonyms:
CHEMBL3289383
Type:
Small organic molecule
Emp. Form.:
C19H22ClFN2OS
Mol. Mass.:
380.907
SMILES:
[O-][S+](CCCN1CCN(CC1)c1ccc(Cl)cc1)c1ccc(F)cc1
Structure:
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