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Target
Xaa-Pro aminopeptidase 2
Ligand
BDBM50078398
Substrate
n/a
Meas. Tech.
ChEMBL_35521 (CHEMBL644754)
IC50
3800±n/a nM
Citation
 Maggiora, LL; Orawski, AT; Simmons, WH Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem 42:2394-402 (1999) [PubMed]  Article 
Target
Name:
Xaa-Pro aminopeptidase 2
Synonyms:
XPP2_RAT | Xpnpep2
Type:
PROTEIN
Mol. Mass.:
76070.70
Organism:
Rattus norvegicus
Description:
ChEMBL_35521
Residue:
674
Sequence:
MAQAYWQCYPWLVLLCACAWSYPGPESLGREDVRDCSTNPPRLPVTAVNTTMRLAALRQQMEKSNLSAYIIPDTDAHMSEYIGKHDERRAWISGFTGSAGTAVVTKKKAAVWTDSRYWTQAERQMDCNWELHKEVSISSIVAWILAEVPDGENVGFDPFLFSVGSWENYDQELQDSNRHLLSITTNLVDVAWGSERPPVPSQPIYALPKEFTGSTWQEKVSAIRSYMQNHTMAPTGVLLSALDETAWLFNLRSSDIPYNPFFYSYTLLTDSSIRLFVNKSRFSLETLQYLNTNCTLPMCVQLEDYSQIRDGVKAYASGNVKILIGISYTTYGVYDVIPKEKLVTETYSPVMLIKAVKNSKEQALLKASHVRDAVAVIQYLVWLEKNVPKGTVDEFSGAEHIDQLRRNENFSSGPSFETISASGLNAALAHYSPTKELHRKLSLDEMYLVDSGGQYWDGTTDITRTVHWGTPTAFQKEAYTRVLMGNIDLSRLVFPAATSGRVVEAFARRALWEVGLNYGHGTGHGIGNFLCVHEWPVGFQYNNMAMAKGMFTSIEPGYYQDGEFGIRLEDVALVVEAKTKYPGTYLTFELVSFVPYDRNLIDVSLLSPEQLQYLNRYYQTIRENIGPELQRRQLLEEFAWLERHTEPLSASAPHTTSLASMWVASALAILSWSC
  
Inhibitor
Name:
BDBM50078398
Synonyms:
2-[(S)-2-((S)-1-Carbamoyl-ethylcarbamoyl)-pyrrolidin-1-yl]-4-phenyl-butyric acid | CHEMBL311925
Type:
Small organic molecule
Emp. Form.:
C18H25N3O4
Mol. Mass.:
347.4088
SMILES:
C[C@H](NC(=O)[C@@H]1CCCN1C(CCc1ccccc1)C(O)=O)C(N)=O
Structure:
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