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Target
Xaa-Pro aminopeptidase 2
Ligand
BDBM50078397
Substrate
n/a
Meas. Tech.
ChEMBL_35515 (CHEMBL644748)
IC50
130±n/a nM
Citation
 Maggiora, LL; Orawski, AT; Simmons, WH Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem 42:2394-402 (1999) [PubMed]  Article 
Target
Name:
Xaa-Pro aminopeptidase 2
Synonyms:
Membrane-bound aminopeptidase P (APP2) | XPNPEP2 | XPP2_HUMAN | Xaa-Pro aminopeptidase 2
Type:
Enzyme
Mol. Mass.:
75618.88
Organism:
Homo sapiens (Human)
Description:
O43895
Residue:
674
Sequence:
MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQMQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWASVLVVSTLAILGWSV
  
Inhibitor
Name:
BDBM50078397
Synonyms:
1-(3-Amino-2-hydroxy-5-methyl-hexanoyl)-pyrrolidine-2-carboxylic acid (1-carbamoyl-ethyl)-amide | CHEMBL420207
Type:
Small organic molecule
Emp. Form.:
C15H28N4O4
Mol. Mass.:
328.4072
SMILES:
CC(C)C[C@@H](N)C(O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O
Structure:
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