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Target
Vasopressin V2 receptor
Ligand
BDBM50078659
Substrate
n/a
Meas. Tech.
ChEBML_214259
IC50
8.3±n/a nM
Citation
 Aranapakam, V; Albright, JD; Grosu, GT; Delos Santos, EG; Chan, PS; Coupet, J; Ru, X; Saunders, T; Mazandarani, H 5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists. Bioorg Med Chem Lett 9:1737-40 (1999) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
AVPR V2 | Antidiuretic hormone receptor | Avpr2 | Renal-type arginine vasopressin receptor | V2R_RAT | VASOPRESSIN V2 | Vasopressin receptor
Type:
G-protein coupled receptor
Mol. Mass.:
40761.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
371
Sequence:
MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
  
Inhibitor
Name:
BDBM50078659
Synonyms:
Biphenyl-2-carboxylic acid [5-(5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl)-pyridin-2-yl]-amide | CHEMBL297705
Type:
Small organic molecule
Emp. Form.:
C31H24N4O2
Mol. Mass.:
484.5479
SMILES:
O=C(Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12)c1ccccc1-c1ccccc1
Structure:
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