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Target
Estrogen receptor
Ligand
BDBM50121317
Substrate
n/a
Meas. Tech.
ChEMBL_1891473 (CHEMBL4393300)
IC50
0.060000±n/a nM
Citation
 Nanjyo, S; Ohgane, K; Yoshioka, H; Makishima, M; Hashimoto, Y; Noguchi-Yachide, T Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton. Bioorg Med Chem 27:1952-1961 (2019) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50121317
Synonyms:
1,1-bis(4,4'-hydroxyphenyl)-2-phenylbut-1-ene | 4,4'-(2-phenylbut-1-ene-1,1-diyl)diphenol | 4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol | CHEMBL149791
Type:
Small organic molecule
Emp. Form.:
C22H20O2
Mol. Mass.:
316.393
SMILES:
[#6]-[#6]\[#6](=[#6](\c1ccc(-[#8])cc1)-c1ccc(-[#8])cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: