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Target
Reverse transcriptase
Ligand
BDBM1633
Substrate
n/a
Meas. Tech.
ChEMBL_1891830 (CHEMBL4393751)
IC50
350±n/a nM
Citation
 Namasivayam, V; Vanangamudi, M; Kramer, VG; Kurup, S; Zhan, P; Liu, X; Kongsted, J; Byrareddy, SN The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic. J Med Chem 62:4851-4883 (2019) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM1633
Synonyms:
2-ethyl-10-methyl-2,4,10-triazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-9-one | Pyridobenzodiazepinone deriv. 11
Type:
Small organic molecule
Emp. Form.:
C15H15N3O
Mol. Mass.:
253.2991
SMILES:
CCN1c2ccccc2N(C)C(=O)c2cccnc12
Structure:
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