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Target
Vesicular acetylcholine transporter
Ligand
BDBM50079278
Substrate
n/a
Meas. Tech.
ChEMBL_213559 (CHEMBL817829)
Ki
0.400000±n/a nM
Citation
 Efange, SM; Khare, AB; Mach, RH; Parsons, SM Hydroxylated decahydroquinolines as ligands for the vesicular acetylcholine transporter: synthesis and biological evaluation. J Med Chem 42:2862-9 (1999) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN
Type:
PROTEIN
Mol. Mass.:
56900.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507628
Residue:
532
Sequence:
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
  
Inhibitor
Name:
BDBM50079278
Synonyms:
(4aR,6R,7R,8aR)-1-((E)-3-Iodo-allyl)-7-(4-phenyl-piperidin-1-yl)-decahydro-quinolin-6-ol | CHEMBL95701 | trans-trans-1-(3-iodoallyl)-7-(4-phenylpiperidin-1-yl)-decahydroquinolin-6-ol
Type:
Small organic molecule
Emp. Form.:
C23H33IN2O
Mol. Mass.:
480.4254
SMILES:
O[C@@H]1C[C@H]2CCCN(C\C=C\I)[C@@H]2C[C@H]1N1CCC(CC1)c1ccccc1
Structure:
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