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Target
Delta-type opioid receptor
Ligand
BDBM50525577
Substrate
n/a
Meas. Tech.
ChEMBL_1897424 (CHEMBL4399459)
Ki
157±n/a nM
Citation
 Sun, S; Jia, Q; Zhang, Z Applications of amide isosteres in medicinal chemistry. Bioorg Med Chem Lett 29:2535-2550 (2019) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50525577
Synonyms:
CHEMBL4531577
Type:
Small organic molecule
Emp. Form.:
C32H42F3N5O9
Mol. Mass.:
697.6992
SMILES:
OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC1(CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)COC1)C(O)=O |r|
Structure:
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