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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50080243
Substrate
n/a
Meas. Tech.
ChEMBL_4309 (CHEMBL618417)
IC50
2±n/a nM
Citation
 Frenette, R; Hutchinson, JH; Léger, S; Thérien, M; Brideau, C; Chan, CC; Charleson, S; Ethier, D; Guay, J; Jones, TR; McAuliffe, M; Piechuta, H; Riendeau, D; Tagari, P; Girard, Y Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. Bioorg Med Chem Lett 9:2391-6 (1999) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50080243
Synonyms:
3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-([1,6]naphthyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid | CHEMBL433133
Type:
Small organic molecule
Emp. Form.:
C33H34ClN3O3S
Mol. Mass.:
588.159
SMILES:
CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4cnccc4n3)cc12
Structure:
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