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Target
High affinity nerve growth factor receptor
Ligand
BDBM50525706
Substrate
n/a
Meas. Tech.
ChEMBL_1897975 (CHEMBL4400010)
IC50
429±n/a nM
Citation
 Subramanian, G; Bowen, SJ; Zhu, Y; Roush, N; Zachary, T; Javens, C; Williams, T; Janssen, A; Gonzales, A Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA). Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
High affinity nerve growth factor receptor
Synonyms:
High affinity nerve growth factor receptor | NTRK1_RAT | Neurotrophic tyrosine kinase receptor type 1 | Ntrk1 | Slow nerve growth factor receptor | Trk | Trk-A | Trka | p140-TrkA
Type:
PROTEIN
Mol. Mass.:
87865.88
Organism:
Rattus norvegicus
Description:
ChEMBL_100078
Residue:
799
Sequence:
MLRGQRHGQLGWHRPAAGLGGLVTSLMLACACAASCRETCCPVGPSGLRCTRAGTLNTLRGLRGAGNLTELYVENQRDLQRLEFEDLQGLGELRSLTIVKSGLRFVAPDAFHFTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALLWLQRWEQEDLCGVYTQKLQGSGSGDQFLPLGHNNSCGVPSVKIQMPNDSVEVGDDVFLQCQVEGQALQQADWILTELEGTATMKKSGDLPSLGLTLVNVTSDLNKKNVTCWAENDVGRAEVSVQVSVSFPASVHLGKAVEQHHWCIPFSVDGQPAPSLRWFFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIMENPQYFSDTCVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDVLG
  
Inhibitor
Name:
BDBM50525706
Synonyms:
CHEMBL4447685
Type:
Small organic molecule
Emp. Form.:
C23H23N7O3
Mol. Mass.:
445.4738
SMILES:
CC(C)(C)c1cc(NC(=O)COC(=O)c2ccc(cc2)-n2cnnn2)n(n1)-c1ccccc1
Structure:
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