Reaction Details Report a problem with these data
Target
Deoxyhypusine hydroxylase
Ligand
BDBM50525976
Substrate
n/a
Meas. Tech.
ChEMBL_1898739 (CHEMBL4400854)
IC50
5000±n/a nM
Citation
 Jiang, Z; You, Q; Zhang, X Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective. Eur J Med Chem 165:172-197 (2019) [PubMed]  Article 
Target
Name:
Deoxyhypusine hydroxylase
Synonyms:
1.14.99.29 | DOHH | DOHH_HUMAN | Deoxyhypusine dioxygenase | Deoxyhypusine hydroxylase | Deoxyhypusine monooxygenase | HEAT-like repeat-containing protein 1 | HLRC1 | Synonyms=HLRC1 | hDOHH
Type:
PROTEIN
Mol. Mass.:
32886.24
Organism:
Homo sapiens
Description:
ChEMBL_119191
Residue:
302
Sequence:
MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS
  
Inhibitor
Name:
BDBM50525976
Synonyms:
APO-066 | APO-66 | CHEBI:68554 | CP-20 | CP20 | DN-180-01-AF | DN-18001AF | Deferiprone | Ferriprox | L-1 | L1 | PL-1 | PL1
Type:
Small organic molecule
Emp. Form.:
C7H9NO2
Mol. Mass.:
139.1519
SMILES:
Cc1c(O)c(=O)ccn1C
Structure:
Search PDB for entries with ligand similarity: