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Target
Relaxin-3 receptor 1
Ligand
BDBM50526408
Substrate
n/a
Meas. Tech.
ChEMBL_1899972 (CHEMBL4402087)
Ki
1700±n/a nM
Citation
 DeChristopher, B; Park, SH; Vong, L; Bamford, D; Cho, HH; Duvadie, R; Fedolak, A; Hogan, C; Honda, T; Pandey, P; Rozhitskaya, O; Su, L; Tomlinson, E; Wallace, I Discovery of a small molecule RXFP3/4 agonist that increases food intake in rats upon acute central administration. Bioorg Med Chem Lett 29:991-994 (2019) [PubMed]  Article 
Target
Name:
Relaxin-3 receptor 1
Synonyms:
G protein-coupled receptor SALPR | G-protein coupled receptor GPCR135 | GPCR135 | RL3R1_HUMAN | RLN3 receptor 1 | RLN3R1 | RXFP3 | Relaxin family peptide receptor 3 | SALPR | Somatostatin- and angiotensin-like peptide receptor
Type:
PROTEIN
Mol. Mass.:
51139.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_818423
Residue:
469
Sequence:
MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGAPPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTATTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
  
Inhibitor
Name:
BDBM50526408
Synonyms:
CHEMBL4586446
Type:
Small organic molecule
Emp. Form.:
C20H21Cl2N5O
Mol. Mass.:
418.32
SMILES:
COc1cc(C)c2[nH]cc(\C=N\NC(=N)NCCc3ccc(Cl)c(Cl)c3)c2c1
Structure:
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