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Target
Tyrosine-protein kinase JAK2
Ligand
BDBM50526461
Substrate
n/a
Meas. Tech.
ChEMBL_1900041 (CHEMBL4402156)
IC50
570±n/a nM
Citation
 Yin, Y; Chen, CJ; Yu, RN; Shu, L; Zhang, TT; Zhang, DY Discovery of novel selective Janus kinase 2 (JAK2) inhibitors bearing a 1H-pyrazolo[3,4-d]pyrimidin-4-amino scaffold. Bioorg Med Chem 27:1562-1576 (2019) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase JAK2
Synonyms:
2.7.10.2 | JAK-2 | JAK2_RAT | Jak2 | Janus kinase 2 | Tyrosine-protein kinase JAK2
Type:
PROTEIN
Mol. Mass.:
130599.57
Organism:
Rattus norvegicus
Description:
ChEMBL_102924
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSPAHQNGDIPGNANSVKQTEPVLQVYLYHSLGQAEGDYLKFPNGEYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNILYRIRFYFPHWYCSGSNRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKEKDQTPLAVYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPDIIDVSIKQANQECSTESRVVTVHKQDGKVLEIELSSLKEALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKRNFSSLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVQLSPTLQRHNNVNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLTLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELANLINTCMDYEPDFRPAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPEGCPDEIYVIMTECWNNNVNQRPSFRDLSLRVDQIRDSMAA
  
Inhibitor
Name:
BDBM50526461
Synonyms:
CHEMBL4561431
Type:
Small organic molecule
Emp. Form.:
C17H18N8O2
Mol. Mass.:
366.3772
SMILES:
Cn1nc(cc1C=O)-c1nn(C2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Structure:
Search PDB for entries with ligand similarity: