Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50081728
Substrate
n/a
Meas. Tech.
ChEBML_139530
IC50
250±n/a nM
Citation
 Choi, KI; Cha, JH; Cho, YS; Pae, AN; Jin, C; Yook, J; Cheon, HG; Jeong, D; Kong, JY; Koh, HY Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors. Bioorg Med Chem Lett 9:2795-800 (1999) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50081728
Synonyms:
3-[1-{3-[4-(4-Methoxy-benzyloxy)-phenyl]-isoxazol-5-yl}-meth-(E)-ylidene]-1-aza-bicyclo[2.2.2]octane | CHEMBL96290
Type:
Small organic molecule
Emp. Form.:
C25H26N2O3
Mol. Mass.:
402.4855
SMILES:
COc1ccc(COc2ccc(cc2)-c2cc(\C=C3\CN4CCC3CC4)on2)cc1 |(27.23,-4.04,;28.76,-3.82,;29.69,-5.04,;31.24,-4.84,;32.18,-6.07,;31.6,-7.5,;32.55,-8.72,;34.08,-8.52,;35.01,-9.72,;36.53,-9.53,;37.47,-10.74,;36.89,-12.16,;35.37,-12.37,;34.43,-11.14,;37.81,-13.37,;37.39,-14.82,;38.66,-15.69,;38.69,-17.24,;37.34,-18.01,;37.34,-19.53,;36,-20.3,;34.69,-19.53,;34.69,-18.01,;36,-17.24,;35.27,-18.94,;36.75,-18.53,;39.85,-14.75,;39.34,-13.32,;30.07,-7.71,;29.11,-6.5,)|
Structure:
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