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Target
Heme oxygenase 2
Ligand
BDBM50526825
Substrate
n/a
Meas. Tech.
ChEMBL_1901237 (CHEMBL4403459)
IC50
3000±n/a nM
Citation
 Intagliata, S; Salerno, L; Ciaffaglione, V; Leonardi, C; Fallica, AN; Carota, G; Amata, E; Marrazzo, A; Pittalą, V; Romeo, G Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Heme oxygenase 2
Synonyms:
HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2
Type:
Enzyme
Mol. Mass.:
35754.99
Organism:
Rattus norvegicus (rat)
Description:
HO-2 obtained from rat brain was used in enzyme assays.
Residue:
315
Sequence:
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
  
Inhibitor
Name:
BDBM50526825
Synonyms:
CHEMBL423457
Type:
Small organic molecule
Emp. Form.:
C17H14N2O
Mol. Mass.:
262.3059
SMILES:
O=C(Cn1ccnc1)c1ccc(cc1)-c1ccccc1
Structure:
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