Reaction Details Report a problem with these data
Target
Low affinity immunoglobulin epsilon Fc receptor
Ligand
BDBM50403719
Substrate
n/a
Meas. Tech.
ChEBML_88888
IC50
70±n/a nM
Citation
 Bailey, S; Bolognese, B; Faller, A; Louis-Flamberg, P; MacPherson, DT; Mayer, RJ; Marshall, LA; Milner, PH; Mistry, J; Smith, DG; Ward, JG Selective inhibition of low affinity IgE receptor (CD23) processing: P1' bicyclomethyl substituents. Bioorg Med Chem Lett 9:3165-70 (1999) [PubMed]  Article 
Target
Name:
Low affinity immunoglobulin epsilon Fc receptor
Synonyms:
BLAST-2 | CD23A | CD_antigen=CD23 | CLEC4J | FCE2 | FCER2 | FCER2_HUMAN | Fc-epsilon-RII | IGEBF | Immunoglobulin E-binding factor | Immunoglobulin epsilon Fc receptor | Low affinity immunoglobulin epsilon Fc receptor | Low affinity immunoglobulin epsilon Fc receptor membrane-bound form | Low affinity immunoglobulin epsilon Fc receptor soluble form | Lymphocyte IgE receptor
Type:
PROTEIN
Mol. Mass.:
36461.84
Organism:
Homo sapiens (Human)
Description:
ChEMBL_88888
Residue:
321
Sequence:
MEEGQYSEIEELPRRRCCRRGTQIVLLGLVTAALWAGLLTLLLLWHWDTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS
  
Inhibitor
Name:
BDBM50403719
Synonyms:
CHEMBL2111687
Type:
Small organic molecule
Emp. Form.:
C21H31N3O5
Mol. Mass.:
405.4879
SMILES:
CC(C)(C)[C@H](NC(=O)C(C[C@@H]1CCc2ccccc2C1)[C@H](O)C(=O)NO)C(N)=O
Structure:
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