Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 3
Ligand
BDBM50528237
Substrate
n/a
Meas. Tech.
ChEMBL_1904603 (CHEMBL4406961)
Kd
72±n/a nM
Citation
 Zhang, H; Xu, L; Qin, X; Chen, X; Cong, H; Hu, L; Chen, L; Miao, Z; Zhang, W; Cai, Z; Zhuang, C -(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[ J Med Chem 62:6665-6681 (2019) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 3
Synonyms:
RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3
Type:
PROTEIN
Mol. Mass.:
56886.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881455
Residue:
518
Sequence:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
  
Inhibitor
Name:
BDBM50528237
Synonyms:
CHEMBL4550952
Type:
Small organic molecule
Emp. Form.:
C27H24FN3O3S
Mol. Mass.:
489.561
SMILES:
Cc1ccc(CC(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)ccc2F)cc1C
Structure:
Search PDB for entries with ligand similarity: