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Target
Cyclin-Y/Cyclin-dependent kinase 16
Ligand
BDBM50528810
Substrate
n/a
Meas. Tech.
ChEMBL_1906433 (CHEMBL4408791)
IC50
10.0±n/a nM
Citation
 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019). Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Cyclin-Y/Cyclin-dependent kinase 16
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1979644
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 16
Synonyms:
CDK16 | CDK16_HUMAN | PCTAIRE1 | PCTK1 | Serine/threonine-protein kinase PCTAIRE-1
Type:
Protein
Mol. Mass.:
55721.58
Organism:
Homo sapiens (Human)
Description:
Q00536
Residue:
496
Sequence:
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF
  
Component 2
Name:
Cyclin-Y
Synonyms:
C10orf9 | CBCP1 | CCNY | CCNY_HUMAN | CFP1 | Cyc-Y | Cyclin box protein 1 | Cyclin fold protein 1 | Cyclin-Y | cyclin-X
Type:
PROTEIN
Mol. Mass.:
39339.72
Organism:
Homo sapiens
Description:
ChEMBL_118346
Residue:
341
Sequence:
MGNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHISDRENIDDLNMEFNPSDHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCSTIFLDDSTVSQPNLKYTIKCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPDYDKHNPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLAEANNLSFPLEPLSRERAHKLEAISRLCEDKYKDLRRSARKRSASADNLTLPRWSPAIIS
  
Inhibitor
Name:
BDBM50528810
Synonyms:
CHEMBL4580787
Type:
Small organic molecule
Emp. Form.:
C28H30Cl3N7O5S
Mol. Mass.:
683.006
SMILES:
CN(C)C\C=C\C(=O)Nc1cccc(c1)S(=O)(=O)N1CCC(CC1)NC(=O)c1n[nH]cc1NC(=O)c1c(Cl)cc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: