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Target
Coagulation factor X
Ligand
BDBM50083998
Substrate
n/a
Meas. Tech.
ChEBML_48476
IC50
2270±n/a nM
Citation
 Marlowe, CK; Sinha, U; Gunn, AC; Scarborough, RM Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: structures based on the (D)-Arg-Gly-Arg tripeptide sequence. Bioorg Med Chem Lett 10:13-6 (2000) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Coagulation factor X | F10 | FA10_BOVIN | Factor Xa (fXa)
Type:
PROTEIN
Mol. Mass.:
54498.45
Organism:
Bos taurus
Description:
ChEMBL_1364435
Residue:
492
Sequence:
MAGLLHLVLLSTALGGLLRPAGSVFLPRDQAHRVLQRARRANSFLEEVKQGNLERECLEEACSLEEAREVFEDAEQTDEFWSKYKDGDQCEGHPCLNQGHCKDGIGDYTCTCAEGFEGKNCEFSTREICSLDNGGCDQFCREERSEVRCSCAHGYVLGDDSKSCVSTERFPCGKFTQGRSRRWAIHTSEDALDASELEHYDPADLSPTESSLDLLGLNRTEPSAGEDGSQVVRIVGGRDCAEGECPWQALLVNEENEGFCGGTILNEFYVLTAAHCLHQAKRFTVRVGDRNTEQEEGNEMAHEVEMTVKHSRFVKETYDFDIAVLRLKTPIRFRRNVAPACLPEKDWAEATLMTQKTGIVSGFGRTHEKGRLSSTLKMLEVPYVDRSTCKLSSSFTITPNMFCAGYDTQPEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIDKIMKARAGAAGSRGHSEAPATWTVPPPLPL
  
Inhibitor
Name:
BDBM50083998
Synonyms:
CHEMBL32044 | [(S)-4-Guanidino-1-({[4-guanidino-1-(4-nitro-phenylcarbamoyl)-butylcarbamoyl]-methyl}-carbamoyl)-butyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C28H39N11O7
Mol. Mass.:
641.6788
SMILES:
NC(=N)NCCCC(NC(=O)CNC(=O)[C@H](CCC[N-]C(N)=[NH2+])NC(=O)OCc1ccccc1)C(=O)Nc1ccc(cc1)[N+]([O-])=O
Structure:
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