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Target
Proton-coupled folate transporter
Ligand
BDBM50529284
Substrate
n/a
Meas. Tech.
ChEMBL_1908224 (CHEMBL4410582)
IC50
49±n/a nM
Citation
Xiang, W; Dekhne, A; Doshi, A; O'Connor, C; Hou, Z; Matherly, LH; Gangjee, A Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor ? and inhibition of de novo purine nucleotide biosynthesis. Bioorg Med Chem 27:0 (2019) [PubMed] Article
More Info.:
Target
Name:
Proton-coupled folate transporter
Synonyms:
G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1
Type:
PROTEIN
Mol. Mass.:
49782.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469597
Residue:
459
Sequence:
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP