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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50529361
Substrate
n/a
Meas. Tech.
ChEMBL_1908491 (CHEMBL4410849)
IC50
26±n/a nM
Citation
 Zhang, H; Liu, K; Pu, Q; Achab, A; Ardolino, MJ; Cheng, M; Deng, Y; Doty, AC; Ferguson, H; Fradera, X; Knemeyer, I; Kurukulasuriya, R; Lam, YH; Lesburg, CA; Martinot, TA; McGowan, MA; Miller, JR; Otte, K; Biju, PJ; Sciammetta, N; Solban, N; Yu, W; Zhou, H; Wang, X; Bennett, DJ; Han, Y Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy. ACS Med Chem Lett 10:1530-1536 (2019) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50529361
Synonyms:
CHEMBL4515137 | US10988487, Example 52
Type:
Small organic molecule
Emp. Form.:
C15H17FN6O4
Mol. Mass.:
364.3317
SMILES:
OCCNC(=O)CNc1nonc1\C(N[C@H]1Cc2ccc(F)cc12)=N\O |r|
Structure:
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