Reaction Details Report a problem with these data
Target
Group XIIB secretory phospholipase A2-like protein
Ligand
BDBM50055366
Substrate
n/a
Meas. Tech.
ChEMBL_1911015 (CHEMBL4413461)
IC50
131±n/a nM
Citation
 Mouchlis, VD; Armando, A; Dennis, EA Substrate-Specific Inhibition Constants for Phospholipase A J Med Chem 62:1999-2007 (2019) [PubMed]  Article 
Target
Name:
Group XIIB secretory phospholipase A2-like protein
Synonyms:
GXIIB | GXIII sPLA2-like | Group XIIB secretory phospholipase A2-like protein | Group XIII secretory phospholipase A2-like protein | PG12B_HUMAN | PLA2G12B | PLA2G13 | PLA2G13 | sPLA2-GXIIB
Type:
PROTEIN
Mol. Mass.:
21657.53
Organism:
Homo sapiens
Description:
ChEMBL_119722
Residue:
195
Sequence:
MKLASGFLVLWLSLGGGLAQSDTSPDTEESYSDWGLRHLRGSFESVNSYFDSFLELLGGKNGVCQYRCRYGKAPMPRPGYKPQEPNGCGSYFLGLKVPESMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEAACDSLVDTVFNTVWTLGCRPFMNSQRAACICAEEEKEEL
  
Inhibitor
Name:
BDBM50055366
Synonyms:
(3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-acetic acid | (3-Aminooxalyl-1-benzyl-2-ethyl-2,3-dihydro-1H-indol-4-yloxy)-acetic acid | 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid | CHEMBL148674 | Varespladib sodium
Type:
Small organic molecule
Emp. Form.:
C21H20N2O5
Mol. Mass.:
380.3939
SMILES:
CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Structure:
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