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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50403825
Substrate
n/a
Meas. Tech.
ChEBML_71309
IC50
5.90±n/a nM
Citation
 Walsh, TF; Toupence, RB; Young, JR; Huang, SX; Ujjainwalla, F; DeVita, RJ; Goulet, MT; Wyvratt, MJ; Fisher, MH; Lo, JL; Ren, N; Yudkovitz, JB; Yang, YT; Cheng, K; Smith, RG Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides. Bioorg Med Chem Lett 10:443-7 (2000) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50403825
Synonyms:
CHEMBL2111955
Type:
Small organic molecule
Emp. Form.:
C27H28ClN5O3S
Mol. Mass.:
538.061
SMILES:
Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3cnsn3)c(Cl)cc2[nH]c1=O |r|
Structure:
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