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Target
M-phase inducer phosphatase 2
Ligand
BDBM50087184
Substrate
n/a
Meas. Tech.
ChEBML_49039
IC50
57000±n/a nM
Citation
 Fritzen, EL; Brightwell, AS; Erickson, LA; Romero, DL The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity. Bioorg Med Chem Lett 10:649-52 (2000) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50087184
Synonyms:
(S)-6,8-Diiodo-7-(4-trifluoromethyl-benzyloxy)-2-[(E)-3-(3,4,5-trimethoxy-phenyl)-acryloyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid | CHEMBL161091
Type:
Small organic molecule
Emp. Form.:
C30H26F3I2NO7
Mol. Mass.:
823.3341
SMILES:
COc1cc(\C=C\C(=O)N2Cc3c(I)c(OCc4ccc(cc4)C(F)(F)F)c(I)cc3C[C@H]2C(O)=O)cc(OC)c1OC
Structure:
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