Reaction Details Report a problem with these data
Target
M-phase inducer phosphatase 2
Ligand
BDBM50087206
Substrate
n/a
Meas. Tech.
ChEBML_49039
IC50
33000±n/a nM
Citation
 Fritzen, EL; Brightwell, AS; Erickson, LA; Romero, DL The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity. Bioorg Med Chem Lett 10:649-52 (2000) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50087206
Synonyms:
(S)-2-[(E)-3-(2-Bromo-phenyl)-acryloyl]-7-(2,4-dichloro-benzyloxy)-6,8-diiodo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid | CHEMBL347911
Type:
Small organic molecule
Emp. Form.:
C26H18BrCl2I2NO4
Mol. Mass.:
813.044
SMILES:
OC(=O)[C@@H]1Cc2cc(I)c(OCc3ccc(Cl)cc3Cl)c(I)c2CN1C(=O)\C=C\c1ccccc1Br
Structure:
Search PDB for entries with ligand similarity: