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Target
Transient receptor potential cation channel subfamily V member 2
Ligand
BDBM50531764
Substrate
n/a
Meas. Tech.
ChEMBL_1920874 (CHEMBL4423719)
IC50
460±n/a nM
Citation
 Chai, H; Cheng, X; Zhou, B; Zhao, L; Lin, X; Huang, D; Lu, W; Lv, H; Tang, F; Zhang, Q; Huang, W; Li, Y; Yang, H Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem 62:1373-1384 (2019) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily V member 2
Synonyms:
Grc | Growth factor-regulated calcium channel | OTRPC2 | Osm-9-like TRP channel 2 | TRPV2_MOUSE | Transient receptor potential cation channel subfamily V member 2 | Trpv2
Type:
PROTEIN
Mol. Mass.:
85969.43
Organism:
Mus musculus
Description:
ChEMBL_119248
Residue:
756
Sequence:
MTSASNPPAFRLETSDGDEEGSAEVNKGKNEPPPMESPFQGEDRNFSPQIKVNLNYRKGLGPSQQDPNRFDRDRLFSVVSRGVPEELTGLLEYLRRTSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACILPLLQIDRDSGNPQPLVNAQCTDEFYRGHSALHIAIEKRSLWCVKLLVENGANVHIRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDSLLQMGARLCPTVQLEDICNHQGLTPLKLAAKEGKIEIFRHILQREFSGLYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPHRHRMVVLEPLNKLLQEKWDRLIPRFFFNFACYLVYMIIFTIVAYHQPSLEQPAIPSSKATFGDSMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLVQALLTVLSQVLRFVETEWYLPLLVSSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDSNTTVTEKPTLGQEEEPVPYGGILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKRHRAGRLLKVGTKGDGIPDERWCFRVEEVNWAAWEKTLPTLSEDPSGAGITGYKKNPTSKPGKNSASEEDHLPLQVLQSH
  
Inhibitor
Name:
BDBM50531764
Synonyms:
CHEMBL1451908
Type:
Small organic molecule
Emp. Form.:
C20H18F3N3O3S
Mol. Mass.:
437.435
SMILES:
COc1ccc(cc1)-c1cc(nc(SCCC(=O)NCc2ccco2)n1)C(F)(F)F
Structure:
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