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Target
AMP deaminase 1
Ligand
BDBM50087317
Substrate
n/a
Meas. Tech.
ChEMBL_31893 (CHEMBL640310)
Ki
18000±n/a nM
Citation
 Bookser, BC; Kasibhatla, SR; Appleman, JR; Erion, MD AMP deaminase inhibitors. 2. Initial discovery of a non-nucleotide transition-state inhibitor series. J Med Chem 43:1495-507 (2000) [PubMed]  Article 
Target
Name:
AMP deaminase 1
Synonyms:
AMP deaminase 1 (hAMPD1) | AMP deaminase isoform M | AMPD1 | AMPD1_HUMAN | Myoadenylate deaminase
Type:
Protein
Mol. Mass.:
90225.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
780
Sequence:
MNVRIFYSVSQSPHSLLSLLFYCAILESRISATMPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE
  
Inhibitor
Name:
BDBM50087317
Synonyms:
3-Octyl-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol 0.25H2O | CHEMBL290949
Type:
Small organic molecule
Emp. Form.:
C14H24N4O
Mol. Mass.:
264.3666
SMILES:
CCCCCCCCn1cnc2C(O)CNC=Nc12 |c:16|
Structure:
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