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Target
Tyrosine-protein phosphatase non-receptor type 4
Ligand
BDBM50531903
Substrate
n/a
Meas. Tech.
ChEMBL_1921368 (CHEMBL4424213)
IC50
30000±n/a nM
Citation
 Buldenko, VM; Trush, VV; Kobzar, OL; Drapailo, AB; Kalchenko, VI; Vovk, AI Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases. Bioorg Med Chem Lett 29:797-801 (2019) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 4
Synonyms:
Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2) | PTN4_HUMAN | PTPN4 | Protein-tyrosine phosphatase MEG1 | Tyrosine-protein phosphatase non-receptor type 4 (PTP-MEG1)
Type:
Protein
Mol. Mass.:
105923.44
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
926
Sequence:
MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSTNK
  
Inhibitor
Name:
BDBM50531903
Synonyms:
CHEMBL4530344
Type:
Small organic molecule
Emp. Form.:
C56H52O12P4
Mol. Mass.:
1040.8999
SMILES:
Oc1c2Cc3cc(CP(O)(=O)c4ccccc4)cc(Cc4cc(CP(O)(=O)c5ccccc5)cc(Cc5cc(CP(O)(=O)c6ccccc6)cc(Cc1cc(CP(O)(=O)c1ccccc1)c2)c5O)c4O)c3O
Structure:
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