Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50087536
Substrate
n/a
Meas. Tech.
ChEBML_48820
Ki
0.100000±n/a nM
Citation
 Pruitt, JR; Pinto, DJ; Estrella, MJ; Bostrom, LL; Knabb, RM; Wong, PC; Wright, MR; Wexler, RR Isoxazolines and isoxazoles as factor Xa inhibitors. Bioorg Med Chem Lett 10:685-9 (2000) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50087536
Synonyms:
3-(3-Carbamimidoyl-phenyl)-isoxazole-4-carboxylic acid (2'-methanesulfonyl-biphenyl-4-yl)-amide | CHEMBL159816
Type:
Small organic molecule
Emp. Form.:
C24H20N4O4S
Mol. Mass.:
460.505
SMILES:
CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2conc2-c2cccc(c2)C(N)=N)cc1
Structure:
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