Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50088371
Substrate
n/a
Meas. Tech.
ChEMBL_148997 (CHEMBL757981)
Ki
160±n/a nM
Citation
 Vianello, P; Albinati, A; Pinna, GA; Lavecchia, A; Marinelli, L; Borea, PA; Gessi, S; Fadda, P; Tronci, S; Cignarella, G Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes. J Med Chem 43:2115-23 (2000) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50088371
Synonyms:
1-[8-(3-Phenyl-allyl)-3,8-diaza-bicyclo[3.2.1]oct-3-yl]-propan-1-one | CHEMBL306002
Type:
Small organic molecule
Emp. Form.:
C18H24N2O
Mol. Mass.:
284.396
SMILES:
CCC(=O)N1CC2CCC(C1)N2C\C=C\c1ccccc1 |TLB:2:4:11:7.8|
Structure:
Search PDB for entries with ligand similarity: