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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50391363
Substrate
n/a
Meas. Tech.
ChEMBL_1924801 (CHEMBL4427757)
IC50
90±n/a nM
Citation
 Röhrig, UF; Majjigapu, SR; Caldelari, D; Dilek, N; Reichenbach, P; Ascencao, K; Irving, M; Coukos, G; Vogel, P; Zoete, V; Michielin, O 1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2). Bioorg Med Chem Lett 26:4330-3 (2016) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50391363
Synonyms:
CHEMBL2148074
Type:
Small organic molecule
Emp. Form.:
C8H6ClN3O
Mol. Mass.:
195.606
SMILES:
Oc1ccc(Cl)cc1-c1c[nH]nn1
Structure:
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