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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50090555
Substrate
n/a
Meas. Tech.
ChEMBL_71729 (CHEMBL680408)
IC50
0.400000±n/a nM
Citation
 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents. Bioorg Med Chem Lett 10:1723-7 (2000) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50090555
Synonyms:
1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrimidin-4-yl-urea | CHEMBL50433
Type:
Small organic molecule
Emp. Form.:
C29H31ClN6O3
Mol. Mass.:
547.048
SMILES:
Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O
Structure:
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