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Target
C-1-tetrahydrofolate synthase, cytoplasmic
Ligand
BDBM50535674
Substrate
n/a
Meas. Tech.
ChEMBL_1931012 (CHEMBL4434263)
IC50
>30000±n/a nM
Citation
 Kawai, J; Ota, M; Ohki, H; Toki, T; Suzuki, M; Shimada, T; Matsui, S; Inoue, H; Sugihara, C; Matsuhashi, N; Matsui, Y; Takaishi, S; Nakayama, K Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett 10:893-898 (2019) [PubMed]  Article 
Target
Name:
C-1-tetrahydrofolate synthase, cytoplasmic
Synonyms:
C-1-tetrahydrofolate synthase, cytoplasmic | C1-THF synthase | C1TC_HUMAN | Formyltetrahydrofolate synthetase | MTHFC | MTHFD | MTHFD1 | Methenyltetrahydrofolate cyclohydrolase | Methylenetetrahydrofolate dehydrogenase
Type:
PROTEIN
Mol. Mass.:
101566.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_257
Residue:
935
Sequence:
MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
  
Inhibitor
Name:
BDBM50535674
Synonyms:
CHEMBL4538051
Type:
Small organic molecule
Emp. Form.:
C20H16N2O4
Mol. Mass.:
348.352
SMILES:
OC(=O)c1ccc(cc1)C(=O)N1CCc2c(C1)c(=O)[nH]c1ccccc21
Structure:
Search PDB for entries with ligand similarity: