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Target
Neutrophil elastase
Ligand
BDBM50093722
Substrate
n/a
Meas. Tech.
ChEBML_63815
IC50
>10000±n/a nM
Citation
 Aoyama, Y; Uenaka, M; Konoike, T; Iso, Y; Nishitani, Y; Kanda, A; Naya, N; Nakajima, M Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors. Bioorg Med Chem Lett 10:2397-401 (2001) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50093722
Synonyms:
(6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-7-methoxy-7-(2-methoxy-benzoylamino)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester | CHEMBL76522
Type:
Small organic molecule
Emp. Form.:
C29H29N5O9S
Mol. Mass.:
623.634
SMILES:
COc1ccccc1C(=O)N[C@@]1(OC)[C@H]2OCC(CSc3nncn3CC(O)=O)=C(N2C1=O)C(=O)OCc1cccc(C)c1 |c:30|
Structure:
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