Reaction Details Report a problem with these data
Target
B2 bradykinin receptor
Ligand
BDBM50093772
Substrate
n/a
Meas. Tech.
ChEBML_40297
Kd
12000±n/a nM
Citation
 Artis, DR; Brotherton-Pleiss, C; Pease, JH; Lin, CJ; Ferla, SW; Newman, SR; Bhakta, S; Ostrelich, H; Jarnagin, K Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor. Bioorg Med Chem Lett 10:2421-5 (2001) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50093772
Synonyms:
CHEMBL311191 | N-[3-(7-Dibenzylamino-3-guanidinomethyl-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-propyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
C35H39N9O
Mol. Mass.:
601.7439
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6]-[#6]-1-[#7]=[#6](-c2ccccc2)-c2cc(ccc2-[#7](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7])-[#6]-1=O)-[#7](-[#6]-c1ccccc1)-[#6]-c1ccccc1 |t:6|
Structure:
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