Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50537921
Substrate
n/a
Meas. Tech.
ChEMBL_1970845 (CHEMBL4603663)
IC50
940±n/a nM
Citation
Lee, JH; Bok, JH; Park, SB; Pagire, HS; Na, YJ; Rim, E; Jung, WH; Song, JS; Kang, NS; Seo, HW; Jung, KY; Lee, BH; Kim, KY; Ahn, JH Optimization of cyclic sulfamide derivatives as 11?-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury. Bioorg Med Chem Lett 30:0 (2020) [PubMed] Article
More Info.:
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
Inhibitor
Name:
BDBM50537921
Synonyms:
CHEMBL4649416
Type:
Small organic molecule
Emp. Form.:
C23H30F3N5O4S
Mol. Mass.:
529.576
SMILES:
CC1CN(CC(=O)NC2C3CC4CC2CC(C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1ccc(cn1)C(F)(F)F |TLB:12:13:17:10.11.16,12:11:8.13.14:17,7:8:10.12.11:14.15.17,7:8:17:10.11.16,THB:16:11:8:14.15.17,16:15:8:10.12.11,(62.19,-24.8,;62.17,-26.34,;63.49,-27.12,;63.47,-28.66,;64.79,-29.44,;66.13,-28.68,;66.15,-27.14,;67.46,-29.46,;68.8,-28.71,;70.56,-28.75,;71.07,-30.08,;72.26,-30.9,;70.63,-30.99,;70.12,-29.56,;71.3,-28.49,;72.93,-28.45,;73.42,-29.89,;71.67,-27.76,;74.25,-27.68,;75.59,-28.44,;74.24,-26.14,;62.13,-29.42,;62.9,-30.75,;61.36,-30.74,;60.81,-28.63,;60.82,-27.09,;59.47,-29.39,;59.46,-30.92,;58.12,-31.68,;56.79,-30.89,;56.8,-29.35,;58.15,-28.6,;55.44,-31.65,;54.12,-30.87,;55.43,-33.19,;54.11,-32.41,)|