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Target
Prothrombin
Ligand
BDBM50094095
Substrate
n/a
Meas. Tech.
ChEMBL_208174 (CHEMBL819080)
Ki
>21000±n/a nM
Citation
 Han, Q; Dominguez, C; Stouten, PF; Park, JM; Duffy, DE; Galemmo, RA; Rossi, KA; Alexander, RS; Smallwood, AM; Wong, PC; Wright, MM; Luettgen, JM; Knabb, RM; Wexler, RR Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors. J Med Chem 43:4398-415 (2000) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50094095
Synonyms:
1-(2-Biphenyl-4-yl-2-oxo-ethyl)-1H-benzoimidazole-5-carboxamidine | CHEMBL136297
Type:
Small organic molecule
Emp. Form.:
C22H18N4O
Mol. Mass.:
354.4045
SMILES:
NC(=N)c1ccc2n(CC(=O)c3ccc(cc3)-c3ccccc3)cnc2c1
Structure:
Search PDB for entries with ligand similarity: