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Target
Genome polyprotein
Ligand
BDBM50094207
Substrate
n/a
Meas. Tech.
ChEMBL_158976 (CHEMBL763743)
IC50
805000±n/a nM
Citation
 Borthwick, AD; Angier, SJ; Crame, AJ; Exall, AM; Haley, TM; Hart, GJ; Mason, AM; Pennell, AM; Weingarten, GG Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template. J Med Chem 43:4452-64 (2000) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
Human rhinovirus A protease | Human rhinovirus B 3A protease
Type:
PROTEIN
Mol. Mass.:
44361.04
Organism:
Human rhinovirus B
Description:
ChEMBL_158953
Residue:
401
Sequence:
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
  
Inhibitor
Name:
BDBM50094207
Synonyms:
1-(2-Acetoxy-acetyl)-3-methyl-2-oxo-octahydro-cyclopenta[b]pyrrole-4-carboxylic acid benzyl ester | CHEMBL344584
Type:
Small organic molecule
Emp. Form.:
C20H23NO6
Mol. Mass.:
373.3997
SMILES:
C[C@@H]1[C@@H]2[C@H](CCC2C(=O)OCc2ccccc2)N(C(=O)COC(C)=O)C1=O
Structure:
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