Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 8
Ligand
BDBM50538736
Substrate
n/a
Meas. Tech.
ChEMBL_1977041 (CHEMBL4610176)
Ki
2400±n/a nM
Citation
 Li, X; Liu, J; Ma, L; Fu, P Pharmacological urate-lowering approaches in chronic kidney disease. Eur J Med Chem 166:186-196 (2019) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 8
Synonyms:
OAT3 | Organic anion transporter 3 | S22A8_HUMAN | SLC22A8 | hOAT3
Type:
PROTEIN
Mol. Mass.:
59870.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1486920
Residue:
542
Sequence:
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS
  
Inhibitor
Name:
BDBM50538736
Synonyms:
CHEMBL4640580
Type:
Small organic molecule
Emp. Form.:
C14H10Br2N2O3
Mol. Mass.:
414.049
SMILES:
Oc1c(Br)cc(cc1Br)C(=O)N1CCOc2ccncc12
Structure:
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