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Target
Serine/threonine-protein kinase DCLK1
Ligand
BDBM50539933
Substrate
n/a
Meas. Tech.
ChEMBL_1979827 (CHEMBL4612962)
IC50
104±n/a nM
Citation
 Ferguson, FM; Liu, Y; Harshbarger, W; Huang, L; Wang, J; Deng, X; Capuzzi, SJ; Muratov, EN; Tropsha, A; Muthuswamy, S; Westover, KD; Gray, NS Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6 J Med Chem 63:7817-7826 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase DCLK1
Synonyms:
DCAMKL1 | DCDC3A | DCLK1 | DCLK1_HUMAN | KIAA0369 | Serine/threonine-protein kinase DCLK1
Type:
PROTEIN
Mol. Mass.:
82239.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774446
Residue:
740
Sequence:
MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
  
Inhibitor
Name:
BDBM50539933
Synonyms:
CHEMBL4648454
Type:
Small organic molecule
Emp. Form.:
C30H38N8O2
Mol. Mass.:
542.6751
SMILES:
COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCN(CC1)C1CCN(C)CC1
Structure:
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