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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50540489
Substrate
n/a
Meas. Tech.
ChEMBL_1981908 (CHEMBL4615170)
Ki
3.5±n/a nM
Citation
 Del Bello, F; Bonifazi, A; Giorgioni, G; Piergentili, A; Sabbieti, MG; Agas, D; Dell'Aera, M; Matucci, R; Górecki, M; Pescitelli, G; Vistoli, G; Quaglia, W Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus. J Med Chem 63:5763-5782 (2020) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50540489
Synonyms:
Flotros | IP-631 | IP631 | Regurin | Regurin xl | Sanctura | Sanctura xr | Spasmo-lyt | Trospium chloride | Uraplex
Type:
Small organic molecule
Emp. Form.:
C25H30ClNO3
Mol. Mass.:
427.964
SMILES:
[Cl-].[H][C@]12CC[C@]([H])(C[C@@H](C1)OC(=O)C(O)(c1ccccc1)c1ccccc1)[N+]21CCCC1 |r,TLB:10:8:27:3.4|
Structure:
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