Reaction Details Report a problem with these data
Target
Proline--tRNA ligase, cytoplasmic
Ligand
BDBM50097090
Substrate
n/a
Meas. Tech.
ChEBML_223470
IC50
26±n/a nM
Citation
 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase. Bioorg Med Chem Lett 11:541-4 (2001) [PubMed]  Article 
Target
Name:
Proline--tRNA ligase, cytoplasmic
Synonyms:
PRS | ProRS | Proline--tRNA ligase | Prolyl-tRNA synthetase | Prolyl-tRNA synthetase, cytoplasmic | SYPC_CANAX
Type:
PROTEIN
Mol. Mass.:
66202.25
Organism:
Candida albicans
Description:
ChEMBL_223470
Residue:
575
Sequence:
MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM
  
Inhibitor
Name:
BDBM50097090
Synonyms:
2-(4-Bromo-phenyl)-6-chloro-quinoline-4-carboxylic acid | CHEMBL153238
Type:
Small organic molecule
Emp. Form.:
C16H9BrClNO2
Mol. Mass.:
362.605
SMILES:
OC(=O)c1cc(nc2ccc(Cl)cc12)-c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: