Reaction Details Report a problem with these data
Target
Cytosolic phospholipase A2 gamma
Ligand
BDBM50085992
Substrate
n/a
Meas. Tech.
ChEBML_52417
IC50
165±n/a nM
Citation
 Seno, K; Okuno, T; Nishi, K; Murakami, Y; Yamada, K; Nakamoto, S; Ono, T Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. Bioorg Med Chem Lett 11:587-90 (2001) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2 gamma
Synonyms:
PA24C_HUMAN | PLA2G4C | Phospholipase A2 group IVC | cPLA2-gamma
Type:
PROTEIN
Mol. Mass.:
60942.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_52417
Residue:
541
Sequence:
MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPEDEGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSCCLA
  
Inhibitor
Name:
BDBM50085992
Synonyms:
CHEMBL268905 | N-[(2S,4R)-1-(2-Benzoyl-benzoyl)-4-(biphenyl-2-ylmethoxy)-pyrrolidin-2-ylmethyl]-4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-benzamide | N-[1-(2-Benzoyl-benzoyl)-4-(biphenyl-2-ylmethoxy)-pyrrolidin-2-ylmethyl]-4-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-benzamide
Type:
Small organic molecule
Emp. Form.:
C43H35N3O6S
Mol. Mass.:
721.82
SMILES:
OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(=O)NC[C@@H]1C[C@H](CN1C(=O)c1ccccc1C(=O)c1ccccc1)OCc1ccccc1-c1ccccc1 |w:7.8,t:1|
Structure:
Search PDB for entries with ligand similarity: