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Target
Cytosolic phospholipase A2 gamma
Ligand
BDBM50059523
Substrate
n/a
Meas. Tech.
ChEBML_52417
IC50
420±n/a nM
Citation
 Seno, K; Okuno, T; Nishi, K; Murakami, Y; Yamada, K; Nakamoto, S; Ono, T Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. Bioorg Med Chem Lett 11:587-90 (2001) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2 gamma
Synonyms:
PA24C_HUMAN | PLA2G4C | Phospholipase A2 group IVC | cPLA2-gamma
Type:
PROTEIN
Mol. Mass.:
60942.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_52417
Residue:
541
Sequence:
MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPEDEGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSCCLA
  
Inhibitor
Name:
BDBM50059523
Synonyms:
(6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one | AACOCF3 | Arachidonic acid trifluoromethyl ketone | Arachidonyl trifluoromethyl ketone | Arachidonyltrifluoromethane | CHEMBL281211
Type:
Small organic molecule
Emp. Form.:
C21H31F3O
Mol. Mass.:
356.4654
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F
Structure:
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