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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50541194
Substrate
n/a
Meas. Tech.
ChEMBL_1983944 (CHEMBL4617350)
EC50
0.800000±n/a nM
Citation
 Ren, A; Zhu, X; Feichtinger, K; Lehman, J; Kasem, M; Schrader, TO; Wong, A; Dang, H; Le, M; Frazer, J; Unett, DJ; Grottick, AJ; Whelan, KT; Morgan, ME; Sage, CR; Semple, G Discovery of a lead series of potent benzodiazepine 5-HT Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50541194
Synonyms:
CHEMBL4646618
Type:
Small organic molecule
Emp. Form.:
C13H18N2
Mol. Mass.:
202.2954
SMILES:
CC1CN2CCNCc3ccc(C)c1c23
Structure:
Search PDB for entries with ligand similarity: