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Target
Endothelin-1 receptor
Ligand
BDBM50098775
Substrate
n/a
Meas. Tech.
ChEMBL_65496 (CHEMBL682969)
IC50
0.17±n/a nM
Citation
 Wu, C; Decker, ER; Blok, N; Li, J; Bourgoyne, AR; Bui, H; Keller, KM; Knowles, V; Li, W; Stavros, FD; Holland, GW; Brock, TA; Dixon, RA Acyl substitution at the ortho position of anilides enhances oral bioavailability of thiophene sulfonamides: TBC3214, an ETA selective endothelin antagonist. J Med Chem 44:1211-6 (2001) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50098775
Synonyms:
3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid (3-cyanomethyl-2,4,6-trimethyl-phenyl)-amide | CHEMBL279471
Type:
Small organic molecule
Emp. Form.:
C21H22N4O4S2
Mol. Mass.:
458.554
SMILES:
Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2c(C)cc(C)c(CC#N)c2C)c1C
Structure:
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