Target
Protein kinase C zeta type
Ligand
BDBM50542119
Substrate
n/a
Meas. Tech.
ChEMBL_1985963 (CHEMBL4619369)
IC50
0.600000±n/a nM
Citation
 Atobe, MSerizawa, TYamakawa, NTakaba, KNagano, YYamaura, TTanaka, ETazumi, ABito, SIshiguro, MKawanishi, M Discovery of 4,6- and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ? Inhibitors with Fragment-Merging Strategy. J Med Chem 63:7143-7162 (2020) [PubMed]  Article 
Target
Name:
Protein kinase C zeta type
Synonyms:
KPCZ_HUMAN | PKC2 | PRKCZ | Protein Kinase C, zeta | Protein kinase C (PKC) | Protein kinase C iota type/zeta type | Protein kinase C zeta | Protein kinase C zeta (PKCζ) | Protein kinase C zeta type | Protein kinase C zeta type (PKC zeta) | Protein kinase C zeta type (PKCzeta) | nPKC-zeta
Type:
Enzyme
Mol. Mass.:
67649.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
592
Sequence:
MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
  
Inhibitor
Name:
BDBM50542119
Synonyms:
CHEMBL4644939
Type:
Small organic molecule
Emp. Form.:
C20H21N3O
Mol. Mass.:
319.4002
SMILES:
Oc1ccc(cc1)-c1cc(NC2CCCNC2)c2ccncc2c1
Structure:
Search PDB for entries with ligand similarity: