Reaction Details Report a problem with these data
Target
Peptide deformylase, mitochondrial
Ligand
BDBM50542163
Substrate
n/a
Meas. Tech.
ChEMBL_1985989 (CHEMBL4619395)
IC50
4.9±n/a nM
Citation
 Hu, L; Cai, X; Dong, S; Zhen, Y; Hu, J; Wang, S; Jiang, J; Huang, J; Han, Y; Qian, Y; Yuan, Y; Hu, W Synthesis and Anticancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors. J Med Chem 63:6959-6978 (2020) [PubMed]  Article 
Target
Name:
Peptide deformylase, mitochondrial
Synonyms:
DEFM_HUMAN | PDF | PDF1A | Peptide deformylase mitochondrial | Peptide deformylase, mitochondrial | Polypeptide deformylase
Type:
PROTEIN
Mol. Mass.:
27023.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154318
Residue:
243
Sequence:
MARLWGALSLWPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWRHLRRLVLGPPEPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVGLSAPQLGVPRQVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRVLDSRLVTFPEGCESVAGFLACVPRFQAVQISGLDPNGEQVVWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND
  
Inhibitor
Name:
BDBM50542163
Synonyms:
CHEMBL4649534
Type:
Small organic molecule
Emp. Form.:
C25H28F4N4O4
Mol. Mass.:
524.5078
SMILES:
ONC(=O)C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1c1nc(no1)-c1ccc(cc1F)C(F)(F)F |r|
Structure:
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